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The drug Synthroid (Levothyroxine) has long been used to treat hypothyroidism and other thyroid gland disorders. To treat the disease effectively, usually, patients are advised to take the pills daily for an hour – half an hour before breakfast. But such a reception scheme for some people can be uncomfortable. Learn more about all possible variants of taking
Synthroid the right way.

What is the Best Time of a Day to Take Levothyroxine?

Time of a day to take synthroidLevothyroxine is taken orally, in the morning on an empty stomach (30 minutes before eating), with a small amount of liquid (1/2 cup water). Do not chew the tablet. The daily dose of the drug is determined individually based on the indications. During the substitution treatment of hypothyroidism, patients under 55 without cardiovascular disease are prescribed levothyroxine in a daily dose of 1.6-1.8 mcg / kg of body weight; patients from 55 years of age or in the presence of violations of the cardiovascular system – 0,9 mcg / kg body weight.

Calculation of the dose with significant obesity should be done on “ideal weight. At the initial stage of replacement therapy for hypothyroidism, patients younger than 55 without cardiovascular disease are prescribed at the following daily doses: Women: 75-100 mcg; Men: 100-150 mcg.

Synthroid tablets correct takingBefore taking the drug, you should read instructions to know whether you that you don’t have any contraindications. Check the list here:

  • Untreated thyrotoxicosis;
  • Acute myocarditis, acute myocardial infarction;
  • Untreated adrenal insufficiency;
  • Hypersensitivity to the components of the drug.

According to the instructions, Levothyroxine should be taken with caution in the presence of cardiovascular diseases: ischemic heart disease (atherosclerosis, angina pectoris, myocardial infarction in history), arrhythmias, arterial hypertension.

Care should also be taken when using Levothyroxine in patients with diabetes mellitus, long-term hypothyroidism with severe course, malabsorption syndrome (dose adjustment may be required). Therapy for hypothyroidism during pregnancy should continue. Simultaneous use with thyreostatics is contraindicated. Women who are breastfeeding should be taken with caution under the supervision of a doctor, with strict adherence to prescribed doses.

Tips for Taking Synthroid Every Morning

  • Tips for taking synthroid (levothyroxine)In the presence of cardiovascular diseases or patients aged 55 years or older, levothyroxine is administered at an initial dose of 25 mcg per day. Prior to the normalization of the thyroid-stimulating hormone level, a dose increase of 25 micrograms is carried out every 2 months in the blood. In case of development or worsening of cardiac symptoms, correction of cardiac treatment should be made.
  •  In the treatment of congenital hypothyroidism, levothyroxine is prescribed depending on age (daily dose / dose in terms of body weight): 0-6 months: 25-50 mcg / 10-15 mcg / kg; 6-12 months: 50-75 mcg / 6-8 mcg / kg; 1-5 years: 75-100 mcg / 5-6 mcg / kg; 6-12 years: 100-150 mcg / 4-5 mcg / kg; More than 12 years: 100-200 mcg / 2-3 mcg / kg. With other indications, the following dosing regimen is prescribed: Euthyroid goiter (treatment and prevention of relapse after its surgical treatment): 75-200 mcg per day; Thyrotoxicosis (complex therapy): 50-100 mcg per day; Thyroid cancer (suppressive therapy): 50-300 mcg per day.
  • Before the thyroid suppression test, levothyroxine is given 75 mcg per day 4 and 3 weeks before the test, 2 and 1 week, 150-200 mcg per day. The daily dose of Levothyroxine to infants is given 30 minutes before the first feeding in one session. The tablet should be dissolved in water to a state of fine suspension (prepared immediately before intake).
  •  In patients with severe form of long-term hypothyroidism, therapy should be started with extreme caution from small doses (12.5 mcg per day). An increase in the dose to the maintenance dose is carried out at longer intervals-every 2 weeks by 12.5 mcg per day. Such patients need to more often determine the level of thyroid-stimulating hormone in the blood. Levothyroxine in hypothyroidism is, as a rule, taken throughout life. In thyrotoxicosis, the drug should be used concomitantly with thyreostatics after reaching the euthyroid state. In all cases, the duration of therapy is determined by the doctor.

Can I Take Synthroid at Night?

Night time to take synthroid levothyroxineUsually, the instructions to drugs indicate when to take the medicine. This is especially important for hormones, as they have biological cycles of producing these hormones. Synthroid (L-thyroxine) before sleep in patients with primary hypothyroidism is associated with higher concentrations of thyroid hormones and lower concentrations of TSH compared to the same doses of L-thyroxine taken in the morning.

The scientists explain their results by the best gastrointestinal absorption of L-thyroxin during the night. When taking L-thyroxin at night, the concentration of TSH will be lower, and the thyroid hormones (T4 and T3) are more. If a person wakes up at 3 o’clock feet, this will lead to the following consequences:

  • There may be a violation of the biological rhythms of the hormone melatonin.
  • You will not have the reverse values (norms) of the content of these hormones for diagnosis and treatment of the thyroid gland.
  • It may be difficult to wake up at 3 o’clock in the morning
  • It will be hard for you to fall asleep after taking the pill
  • Such a life with nightly awakenings for taking medication can lead you to insomnia

What to Do if I Miss a Dose?

If you miss the dosage, you mustn’t double it. When an overdose is observed, there is a risk to have thyrotoxic crisis, manifested by such symptoms as hyperhidrosis, tachycardia, weight loss, exophthalmos, tremor of fingers. In this case, it is necessary to reduce the dose of the drug. In the case of acute intoxication, plasmapheresis and gastric lavage are recommended. Also, the appointment of glucocorticosteroids, colestyramine, cardiac glycosides, beta-adrenoblockers and oxygen therapy. It is contraindicated to take antithyroid drugs.

In some schemes, it is allowed to skip Synthroid intake 1 day a week or 2 days a week, but not in a row. About this scheme the doctor, usually, will tell at the reception. This applies to patients suffering from arrhythmia, and elderly patients (over 75 years old), etc.

What Medications Shouldn’t Be Taken with Synthroid?

With the simultaneous use of Synthroid (levothyroxine) with certain drugs, the following effects may occur:

  • Indirect anticoagulants: an increase in their action (may require a decrease in their dose);
  • Tricyclic antidepressants: strengthening their action;
  • Estrogen-containing drugs: an increase in the content of thyroxin-binding globulin (an increase in the dose of levothyroxine sodium may be required);
  • Insulin, oral hypoglycemic drugs: increased demand for them; Cardiac glycosides: a decrease in their action;
  • Cholestyramine, colestipol, aluminum hydroxide: a decrease in the plasma concentration of levothyroxine sodium;
  • Anabolic steroids, asparaginase, tamoxifen: pharmacokinetic interaction at the level of binding to proteins;
  • Phenytoin, salicylates, clofibrate, furosemide (in high doses): an increase in the content of non-protein-bound plasma of levothyroxine sodium;
  • Somatotropin: accelerating the closure of epiphyseal growth zones;
  • Phenobarbital, carbamazepine, rifampicin: increased clearance of levothyroxine sodium.

Can You Drink Coffee after Taking Synthroid?

Drinking coffee after taking Sinthroid (Levothiroxine)Coffee directly affects the degree of absorption by the human body of most modern medicines. An invigorating drink can strengthen several times the action of some drugs and slow down, or even block the effect of other drugs. The most active component of coffee is caffeine, which in most cases interacts with the components of medicinal compounds. However, other components of coffee are also able to react with drugs. Interacting with coffee, the nature of the impact on the human body changes completely in estrogenic drugs, antidepressants, drugs for the treatment of osteoporosis and thyroid diseases.

Caffeine is a widely available substance found in coffee, tea, soft drinks, sports drinks and chocolate. Caffeine can be contained in certain medicines. Like many other medicines, caffeine affects the ability of the body to metabolize levothyroxine. It is taken always before meals for 20-30 minutes washed down with water (not tea or coffee).

Coffee, other drinks and products containing caffeine are recommended to be taken no earlier than 6 hours after taking GG.

So, a cup of coffee in the morning with taking levothyroxine should be excluded from your ration to preserve health.